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Contraindicated (1)pentobarbital decreases levels of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay away from coadministration with powerful CYP3A4 inducers; these medicines decrease publicity to vandetanib by as many as forty%.fentanyl iontophoretic transdermal program and pentobarbital both of those imp